Incretins

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What Is Incretins?

Incretins are group of hormones that plays important role in glucose metabolism. Incretins are also known as gut hormones because these hormones secrete from enteroendocrine cells within minutes after taking meals.

There are two major Incretins and both rapidly activates in the presence of enzyme DPP – 4 .

  • GLP 1 (Glucagon-like peptide)
  • GIP (Gucose-dependent insulinotropic polypeptide)

What Is Incretin Effects?

Incretins are used for Insulin stimulation and Gucagon suppression.Therefore It is a new class of medicines for treating type 2 diabetes.

What dose Incretin mimetic Effect?

Incretin minetics mimic the actions of Incretins. Incretin minetics binds GLP 1 Receptors on pancreatic beta-cells and activates them for stimulating Insulin.

What are Incretin drugs?

  • Alogliptin
  • Exenatide
  • Linagliptin
  • Liraglutide
  • Saxagliptin
  • Sitagliptin
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